Congrats to all of our 2012 seniors! We will surely miss all of them. Congrats to our following seniors: Kat Salvadora, Kevin Pham, Kevin Lee, Thomas Lee, Victor Ramos, and Vince Caganot...
UROP 2012 Symposium
Read more >>
ISAMS 2011 Conference
Read More >>
>> September 18, 2011
Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat. [Link]
>> April 22, 2011
Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. [Link]
>> July 20, 2010
Curcumin Extends Lifespan, Improves Heal Span, and Modulate Aging Related Genes in Drosophila Melanogaster. [Link]
>> July 1, 2010
Drosophila Melanogaster as a Model System for Evaluating Anti-aging Compounds. [Link]
>> May 29, 2009
Can Drosophila melanogaster Represent a Model System for the Detection of Reproductive Adverse Drug Reactions? [Link]
>> The objective of our lab is to increase lifespan and improve health by natural products (e.g. botanical extracts).
>> We use various model systems such as human cultured cells, fruit flies, and mice to study the impacts of natural products on longevity and health.
>> Our ultimate goal is to test these botanicals in humans.
>> We hypothesize that botanicals extend lifespan and enhance health span by modulating one or more of the major pathways of aging: mitochondrial bioenergetics, oxidative stress, insulin signaling, sirtuins, and target of rapamycin (TOR).
Mahtab Jafari discusses therapeutic intervention on aging pathways and her work determining the mechanism of botanicals which her group has shown to extend life span in the fruit fly, Drosophila.
Drosophila melanogaster: This model organism is now considered an established and effective tool for analyzing the function of human disease genes.
About 75% of known human disease genes have a recognizable match in the genome of fruit flies and 50% of fly protein sequences have mammalian homologs.